cenobamate will reduce the extent or impact of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Maximize dose of CYP3A4 substrate, as required, when coadministered with cenobamate.brimonidine and fentanyl transdermal the two boost sedation. Stay away from or Use Alternate Drug. Limit u